Sitagliptin Reduces Endothelial Dysfunction and Apoptosis Induced by High-Fat Diet and Palmitate in Thoracic Aortas and Endothelial Cells via ROS-ER Stress-CHOP Pathway

Sitagliptin Reduces Endothelial Dysfunction and Apoptosis Induced by High-Fat Diet and Palmitate in Thoracic Aortas and Endothelial Cells via ROS-ER Stress-CHOP Pathway

Macrovascular disease is tightly associated with obesity-induced metabolic syndrome. Sitagliptin (SIT), an orally stable selective inhibitor of Dipeptidyl peptidase-4 (DPP-4), has protective effects on endothelium. However, the mechanisms enabling SIT to exhibit resistance to diet-induced obesity (D...

Full description

Bibliographic Details
Main Authors: Qiongqiong Cao, Dongmei Xu, Yong Chen, Yueming Long, Fang Dai, Li Gui, Yunxia Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
sitagliptin
high-fat diet
palmitate
endoplasmic reticulum stress
thoracic aorta
human umbilical vein endothelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.670389/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.670389/full

Similar Items