Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity

Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity

Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. Adipose tissue is the main source of circulating ATX that modulates plasma LPA levels. Upregulation of ATX expression in obese pati...

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Bibliographic Details
Main Authors: Shuhong Sun, Ran Wang, Jianwen Song, Ming Guan, Na Li, Xiaotian Zhang, Zhenwen Zhao, Junjie Zhang
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Journal of Lipid Research
Subjects:
glycoprotein 130
autotaxin
adipocyte
insulin sensitivity
obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520338013

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http://www.sciencedirect.com/science/article/pii/S0022227520338013

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