Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors

Acidic tissue microenvironment contributes to tumor progression via multiple effects including the activation of angiogenic factors and proteases, reduced cell-cell adhesion, increased migration and invasion, etc. In addition, intratumoral acidosis can influence the uptake of anticancer drugs and mo...

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Bibliographic Details
Main Authors: Olga eSedlakova, Eliska eSvastova, Martina eTakacova, Juraj eKopacek, Jaromir ePastorek, Silvia ePastorekova
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Physiology
Subjects:
Acidosis
Metabolism
Survival
Tumor Microenvironment
metastasis
hypoxia
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00400/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00400/full

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