Endotoxemia-Induced Release of Pro-inflammatory Mediators Are Associated With Increased Glomerular Filtration Rate in Humans in vivo

Endotoxemia-Induced Release of Pro-inflammatory Mediators Are Associated With Increased Glomerular Filtration Rate in Humans in vivo

Introduction: Sepsis is the most prevalent cause of Acute Kidney Injury (AKI). Conversely, in some septic patients the glomerular filtration rate (GFR) is augmented. The role of the inflammatory response and blood pressure to induce this increased GFR is unknown. Herein, we relate inflammatory media...

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Bibliographic Details
Main Authors: Remi Beunders, Maren J. Schütz, Roger van Groenendael, Guus P. Leijte, Matthijs Kox, Lucas T. van Eijk, Peter Pickkers
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Medicine
Subjects:
augmented renal clearance
sepsis
acute kidney injury
systemic inflammation
iohexol plasma clearance
glomerular filtration rate
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2020.559671/full

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https://www.frontiersin.org/articles/10.3389/fmed.2020.559671/full

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