Distinct Shift in Beta-Cell Glutaredoxin 5 Expression Is Mediated by Hypoxia and Lipotoxicity Both In Vivo and In Vitro

Distinct Shift in Beta-Cell Glutaredoxin 5 Expression Is Mediated by Hypoxia and Lipotoxicity Both In Vivo and In Vitro

Histomorphological and functional alterations in pancreatic islet composition directly correlate with hyperglycemia severity. Progressive deterioration of metabolic control in subjects suffering from type 2 diabetes is predominantly caused by impaired beta-cell functionality. The glutaredoxin system...

Full description

Bibliographic Details
Main Authors: Sebastian Friedrich Petry, Lia Mingzhe Sun, Anna Knapp, Sabrina Reinl, Thomas Linn
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Endocrinology
Subjects:
diabetes mellitus type 2
glutaredoxin
islet remodeling
rodent diabesity
db mouse
MIN6
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00084/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2018.00084/full

Similar Items