CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model

CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model

Cluster of differentiation 226 (CD226) molecules play a crucial role in the activation of effector CD4+ T cells during the immune response process, but a cell-intrinsic function of CD226 in CD4+ T subsets is not clear. In this study, we showed that Cd226−/− mice were resistant to myelin oligodendroc...

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Bibliographic Details
Main Authors: Ning Wang, Hongyu Yi, Liang Fang, Jingyi Jin, Qianli Ma, Yuting Shen, Juan Li, Shuang Liang, Jie Xiong, Zhuo Li, Hanyu Zeng, Fengliang Jiang, Boquan Jin, Lihua Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
CD226
EAE
Tregs
proliferation
suppression
Akt signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01883/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01883/full

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