Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB

Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB

A significant subpopulation of neurons in rat nucleus accumbens (NAc) coexpress dopamine D1 and D2 receptors, which can form a D1-D2 receptor complex, but their relevance in addiction is not known. The existence of the D1-D2 heteromer in the striatum of rat and monkey was established using in situ P...

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Bibliographic Details
Main Authors: Ahmed Hasbi, Melissa L. Perreault, Maurice Y. F. Shen, Theresa Fan, Tuan Nguyen, Mohammed Alijaniaram, Tomek J. Banasikowski, Anthony A. Grace, Brian F. O'Dowd, Paul J. Fletcher, Susan R. George
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
addiction and addiction behaviors
dopamine D1-D2 heteromer
DARPP-32
deltaFosB
dopamine signaling
proximity ligation assay
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00924/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00924/full

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