Piperaquine resistant Cambodian Plasmodium falciparum clinical isolates: in vitro genotypic and phenotypic characterization

Piperaquine resistant Cambodian Plasmodium falciparum clinical isolates: in vitro genotypic and phenotypic characterization

Abstract Background High rates of dihydroartemisinin–piperaquine (DHA–PPQ) treatment failures have been documented for uncomplicated Plasmodium falciparum in Cambodia. The genetic markers plasmepsin 2 (pfpm2), exonuclease (pfexo) and chloroquine resistance transporter (pfcrt) genes are associated wi...

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Bibliographic Details
Main Authors: Nonlawat Boonyalai, Brian A. Vesely, Chatchadaporn Thamnurak, Chantida Praditpol, Watcharintorn Fagnark, Kirakarn Kirativanich, Piyaporn Saingam, Chaiyaporn Chaisatit, Paphavee Lertsethtakarn, Panita Gosi, Worachet Kuntawunginn, Pattaraporn Vanachayangkul, Michele D. Spring, Mark M. Fukuda, Chanthap Lon, Philip L. Smith, Norman C. Waters, David L. Saunders, Mariusz Wojnarski
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Malaria Journal
Subjects:
Drug combination
Exonuclease
Malaria
PfCRT
Piperaquine resistance
Plasmepsin
Online Access:http://link.springer.com/article/10.1186/s12936-020-03339-w

Internet

http://link.springer.com/article/10.1186/s12936-020-03339-w

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