Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers

Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers

Ischemia/reperfusion (I/R) injury unavoidably occurs during hepatic resection and transplantation. Aged livers poorly tolerate I/R during surgical treatment. Although livers have a powerful endogenous inhibitor of calpains, calpastatin (CAST), I/R activates calpains, leading to impaired autophagy, m...

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Bibliographic Details
Main Authors: Joseph Flores-Toro, Sung-Kook Chun, Jun-Kyu Shin, Joan Campbell, Melissa Lichtenberger, William Chapman, Ivan Zendejas, Kevin Behrns, Christiaan Leeuwenburgh, Jae-Sung Kim
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
liver
ischemia/reperfusion
autophagy
mitochondria
calpastatin
Online Access:https://www.mdpi.com/2073-4409/10/8/1863

Internet

https://www.mdpi.com/2073-4409/10/8/1863

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