The Bacterial Protein CNF1 as a Potential Therapeutic Strategy against Mitochondrial Diseases: A Pilot Study

The Bacterial Protein CNF1 as a Potential Therapeutic Strategy against Mitochondrial Diseases: A Pilot Study

The Escherichia coli protein toxin cytotoxic necrotizing factor 1 (CNF1), which acts on the Rho GTPases that are key regulators of the actin cytoskeleton, is emerging as a potential therapeutic tool against certain neurological diseases characterized by cellular energy homeostasis impairment. In thi...

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Bibliographic Details
Main Authors: Alessia Fabbri, Sara Travaglione, Zaira Maroccia, Marco Guidotti, Ciro Leonardo Pierri, Guido Primiano, Serenella Servidei, Stefano Loizzo, Carla Fiorentini
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
cytotoxic necrotizing factor 1
mitochondrial diseases
myoclonic epilepsy with ragged red fibers syndrome
actin cytoskeleton
adenosine triphosphate
Online Access:http://www.mdpi.com/1422-0067/19/7/1825

Internet

http://www.mdpi.com/1422-0067/19/7/1825

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