A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis

A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis

Abstract Caspase-11, a cytosolic lipopolysaccharide (LPS) receptor, mediates lethal immune responses and coagulopathy in sepsis, a leading cause of death worldwide with limited therapeutic options. We previously showed that over-activation of caspase-11 is driven by hepatocyte-released high mobility...

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Bibliographic Details
Main Authors: Xiangyu Wang, Zhaozheng Li, Yang Bai, Rui Zhang, Ran Meng, Fangping Chen, Haichao Wang, Timothy R. Billiar, Xianzhong Xiao, Ben Lu, Yiting Tang
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03652-5

Internet

https://doi.org/10.1038/s41419-021-03652-5

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