Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration

Innate immune activation and chronic neuroinflammation are characteristic features of many neurodegenerative diseases including Parkinson's disease (PD) and may contribute to the pathophysiology of the disease. The discovery of misfolded alpha-synuclein (αSYN) protein aggregates, which amplify...

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Bibliographic Details
Main Authors: Javier María Peralta Ramos, Pablo Iribarren, Luc Bousset, Ronald Melki, Veerle Baekelandt, Anke Van der Perren
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
inflammation
alpha-synuclein
inflammatory monocytes
Parkinson's disease
synucleinopathies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00080/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00080/full

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