Checkpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells

Checkpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells

Abstract Background AZD7762 is a checkpoint kinase 1 (Chk 1) inhibitor, which has been reported to sensitize many tumor cells to DNA damage. However, whether AZD7762 could sensitize osteosarcoma cells to chemotherapy cisplatin has not been defined. Methods We used a variety of methods such as cell v...

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Bibliographic Details
Main Authors: Jian Zhu, Hanhui Zou, Wei Yu, Yuluan Huang, Bing Liu, Tao Li, Chengzhen Liang, Huimin Tao
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cancer Cell International
Subjects:
AZD7762
Cisplatin
Osteosarcoma
Apoptosis
Chk1
Online Access:http://link.springer.com/article/10.1186/s12935-019-0896-9

Internet

http://link.springer.com/article/10.1186/s12935-019-0896-9

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