Myogenin promotes myocyte fusion to balance fibre number and size

Loss of the transcription factor Myogenin in mice reduces skeletal myogenesis and leads to perinatal death but how Myogenin regulates muscle formation is unclear. Here, the authors show that zebrafish Myogenin enhances Myomaker expression, muscle cell fusion and myotome size, yet decreases fast musc...

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Bibliographic Details
Main Authors: Massimo Ganassi, Sara Badodi, Huascar Pedro Ortuste Quiroga, Peter S. Zammit, Yaniv Hinits, Simon M. Hughes
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06583-6