Ibudilast-Induced Decreases in Cytosolic Ca2+ Level and Contraction in Rat Aorta
The mechanism by which ibudilast induces vasodilation was examined in isolated endothelium-denuded rat aorta. Ibudilast inhibited the contractions induced by phenylephrine (PE) and high K+ with decrease of [Ca2+]i level in a concentration-dependent manner, to the same degree. 3-Isobutyl-1-methylxant...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2007-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319342288 |