Down-Regulation of Renal Klotho Expression by Shiga Toxin 2

Down-Regulation of Renal Klotho Expression by Shiga Toxin 2

Background/Aims: Shiga toxin 2 may trigger classical hemolytic uremic syndrome (HUS) eventually leading to renal failure. Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney is involved in the regulation of renal phosphate excretion and also retains renal protective effe...

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Bibliographic Details
Main Authors: Martina Feger, Sobuj Mia, Tatsiana Pakladok, Jan P. Nicolay, Ioana Alesutan, Stefan W. Schneider, Jakob Voelkl, Florian Lang
Format: Article
Language:English
Published: Karger Publishers 2014-11-01
Series:Kidney & Blood Pressure Research
Subjects:
25-hydroxyvitamin D3 1-α-hydroxylase
phosphate
p38 MAPK
1,25(OH)2D3
klotho
FGF23
Online Access:http://www.karger.com/Article/FullText/368457

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http://www.karger.com/Article/FullText/368457

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