NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy alone provide an incomplete view of disease. We have tested here the relevance of additional homeostatic deviations that result from loss...

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Bibliographic Details
Main Authors: Ana I. Rojo, Marta Pajares, Patricia Rada, Angel Nuñez, Alejo J. Nevado-Holgado, Richard Killik, Fred Van Leuven, Elena Ribe, Simon Lovestone, Masayuki Yamamoto, Antonio Cuadrado
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Redox Biology
Subjects:
NRF2
Alzheimer's disease
Transcriptomics
Proteotoxicity
Neuroinflammation
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717303993

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http://www.sciencedirect.com/science/article/pii/S2213231717303993

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