Mixed Lineage Leukemia 1 Promoted Neuron Apoptosis in Ischemic Penumbra via Regulating ASK-1/TNF-α Complex

Mixed Lineage Leukemia 1 Promoted Neuron Apoptosis in Ischemic Penumbra via Regulating ASK-1/TNF-α Complex

Neuron apoptosis in ischemic penumbra was proved to be involved in ischemic stroke (IS) development and contributed to the poor prognosis of IS. Recent studies showed that aberrant trimethylation of histone H3 lysine 4 (H3K4me3) level was associated with cell apoptosis. This study aimed to explore t...

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Bibliographic Details
Main Authors: Zhang Feng, Liu Jie, Lv Guimin, Wang Xi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Neuroanatomy
Subjects:
mixed lineage leukemia 1
histone methylation
ischemic stroke
apoptosis
prognosis
Online Access:https://www.frontiersin.org/article/10.3389/fnana.2020.00036/full

Internet

https://www.frontiersin.org/article/10.3389/fnana.2020.00036/full

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