Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles

Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles

Antigen presenting cells induce CD4+ T helper (Th) differentiation upon pathogen encounters. Here the authors use fluorescently-labeled bacteria, helminth and fungi to track and describe the functions of IRF4+ migratory type 2 dendritic cells and monocytes in the specific induction of Th1, Th2 or Th...

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Bibliographic Details
Main Authors: Kerry L. Hilligan, Shiau-Choot Tang, Evelyn J. Hyde, Elsa Roussel, Johannes U. Mayer, Jianping Yang, Kirsty A. Wakelin, Alfonso J. Schmidt, Lisa M. Connor, Alan Sher, Andrew S. MacDonald, Franca Ronchese
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19463-9

Internet

https://doi.org/10.1038/s41467-020-19463-9

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