Exploring the active site of the Streptococcus pneumoniae topoisomerase IV–DNA cleavage complex with novel 7,8-bridged fluoroquinolones

Exploring the active site of the Streptococcus pneumoniae topoisomerase IV–DNA cleavage complex with novel 7,8-bridged fluoroquinolones

As part of a programme of synthesizing and investigating the biological properties of new fluoroquinolone antibacterials and their targeting of topoisomerase IV from Streptococcus pneumoniae, we have solved the X-ray structure of the complexes of two new 7,8-bridged fluoroquinolones (with restricted...

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Bibliographic Details
Main Authors: Ivan Laponogov, Xiao-Su Pan, Dennis A. Veselkov, Ryan T. Cirz, Allan Wagman, Heinz E. Moser, L. Mark Fisher, Mark R. Sanderson
Format: Article
Language:English
Published: The Royal Society 2016-01-01
Series:Open Biology
Subjects:
topoisomerases
protein–dna complexes
drug design
x-ray crystallography
dna topological experiments
mic determinants
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160157

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160157

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