Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum

Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum

Abstract Background Severe malarial anemia (SMA) is a leading cause of malaria-related morbidity and mortality in children. The genetic factors that influence development of SMA and inefficient erythropoiesis, a central pathogenic feature of SMA, are only partially understood. Methods We performed a...

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Bibliographic Details
Main Authors: Lily E. Kisia, Prakasha Kempaiah, Samuel B. Anyona, Elly O. Munde, Angela O. Achieng, John M. Ong’echa, Christophe G. Lambert, Kiprotich Chelimo, Collins Ouma, Douglas J. Perkins, Evans Raballah
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Medical Genetics
Subjects:
IL7 variation
Plasmodium falciparum
Severe malarial anemia
Inefficient erythropoiesis
Online Access:http://link.springer.com/article/10.1186/s12881-019-0866-z

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http://link.springer.com/article/10.1186/s12881-019-0866-z

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