The Delivery of α1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore

The Delivery of α1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore

Human α1-antitrypsin (AAT) is an abundant acute phase glycoprotein expressing anti-protease and immunomodulatory activities, and is used as a biopharmaceutical to treat patients with inherited AAT deficiency. The pleiotropic properties of AAT provide a rationale for using this therapy outside of inh...

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Bibliographic Details
Main Authors: Srinu Tumpara, Beatriz Martinez-Delgado, Gema Gomez-Mariano, Bin Liu, David S. DeLuca, Elena Korenbaum, Danny Jonigk, Frank Jugert, Florian M. Wurm, Maria J. Wurm, Tobias Welte, Sabina Janciauskiene
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
alpha1-antitrypin
Inflammation Immunomodulation
epidermis
topical-Skin cream
RNA-Seq-RNA sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00983/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00983/full

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