Recombinant Klotho protein enhances cholesterol efflux of THP-1 macrophage-derived foam cells via suppressing Wnt/β-catenin signaling pathway

Recombinant Klotho protein enhances cholesterol efflux of THP-1 macrophage-derived foam cells via suppressing Wnt/β-catenin signaling pathway

Abstract Background Atherosclerosis (AS) is the basis of cardiovascular diseases, characterized by chronic inflammatory and lipid metabolism disorders. Although the anti-inflammatory effect of Klotho in AS has been clearly shown, its lipid-lowering effect is unclear. In this study, we examined the e...

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Bibliographic Details
Main Authors: Wei Liu, Xiujuan Chen, Min Wu, Lin Li, Jiani Liu, Jing Shi, Tian Hong
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Cardiovascular Disorders
Subjects:
Recombinant Klotho protein
Cholesterol efflux
THP-1 macrophage-derived foam cells
Wnt/β-catenin signaling pathway
Atherosclerosis
Online Access:http://link.springer.com/article/10.1186/s12872-020-01400-9

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http://link.springer.com/article/10.1186/s12872-020-01400-9

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