Analysis of Prion Strains by PrP(Sc) Profiling in Sporadic Creutzfeldt-Jakob Disease.
BACKGROUND: Prion diseases are a group of invariably fatal neurodegenerative disorders affecting humans and a wide range of mammals. An essential part of the infectious agent, termed the prion, is composed of an abnormal isoform (PrP(Sc)) of a host-encoded normal cellular protein (PrP(C)). The conve...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-12-01
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| Series: | PLoS Medicine |
| Online Access: | http://dx.doi.org/10.1371/journal.pmed.0030014 |