Origin of mutations in genes associated with human glioblastoma multiform cancer: random polymerase errors versus deamination
The etiology of glioblastoma multiforme (GBM), the most serious form of brain cancer, remains obscure, although it has been proposed that cancer risk is a function of random polymerase errors that occur during stem cell division and the resulting mutations in oncogenes and tumor suppressor genes. An...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-03-01
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Series: | Heliyon |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844018331311 |