Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells.

Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells.

Detection and elimination of virus-infected cells by CD8(+) cytotoxic T lymphocytes (CTLs) depends on recognition of virus-derived peptides presented by major histocompatibility complex class I (MHC-I) molecules on the surface of infected cells. In the present study, we showed that inactivation of t...

Full description

Bibliographic Details
Main Authors: Takahiko Imai, Naoto Koyanagi, Ryo Ogawa, Keiko Shindo, Tadahiro Suenaga, Ayuko Sato, Jun Arii, Akihisa Kato, Hiroshi Kiyono, Hisashi Arase, Yasushi Kawaguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3741198?pdf=render

Internet

http://europepmc.org/articles/PMC3741198?pdf=render

Similar Items