The Wnt gatekeeper SFRP4 modulates EMT, cell migration and downstream Wnt signalling in serous ovarian cancer cells.

The Wnt gatekeeper SFRP4 modulates EMT, cell migration and downstream Wnt signalling in serous ovarian cancer cells.

Aberrant Wnt signalling is implicated in numerous human cancers, and understanding the effects of modulation of pathway members may lead to the development of novel therapeutics. Expression of secreted frizzled related protein 4 (SFRP4), an extracellular modulator of the Wnt signalling pathway, is p...

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Bibliographic Details
Main Authors: Caroline E Ford, Eve Jary, Sean Si Qian Ma, Sheri Nixdorf, Viola A Heinzelmann-Schwarz, Robyn L Ward
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3543420?pdf=render

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http://europepmc.org/articles/PMC3543420?pdf=render

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