Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte

Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte

Intestinal cholesterol absorption is a major determinant of plasma low density lipoprotein-cholesterol (LDL33333391) concentrations. Ezetimibe (SCH 58235) and its analogs SCH 48461 and SCH 58053 are novel potent inhibitors of cholesterol absorption whose mechanism of action is unknown. These studies...

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Bibliographic Details
Main Authors: Joyce J. Repa, John M. Dietschy, Stephen D. Turley
Format: Article
Language:English
Published: Elsevier 2002-11-01
Series:Journal of Lipid Research
Subjects:
liver
small intestine
bile acid
cholesterol efflux
cholesterol synthesis
fecal neutral sterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520327619

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http://www.sciencedirect.com/science/article/pii/S0022227520327619

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