MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner

MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner

MALT1 is a central signaling component in innate and adaptive immunity by regulating NF-κB and other key signaling pathways in different cell types. Activities of MALT1 are mediated by its scaffold and protease functions. Because of its role in lymphocyte activation and proliferation, inhibition of...

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Bibliographic Details
Main Authors: Annelies Demeyer, Ioannis Skordos, Yasmine Driege, Marja Kreike, Tino Hochepied, Mathijs Baens, Jens Staal, Rudi Beyaert
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
inflammation
Treg
Breg
CTLA-4
paracaspase
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01898/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01898/full

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