Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples

Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples

Abstract Background Tumour-associated macrophages (TAMs) are often implicated in cancer progression but can also exert anti-tumour activities. Selective eradication of cancer-promoting (M2-like) TAM subsets is a highly sought-after goal. Here, we have devised a novel strategy to achieve selective TA...

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Bibliographic Details
Main Authors: Eleanor M. Scott, Egon J. Jacobus, Brian Lyons, Sally Frost, Joshua D. Freedman, Arthur Dyer, Hena Khalique, William K. Taverner, Alison Carr, Brian R. Champion, Kerry D. Fisher, Len W. Seymour, Margaret R. Duffy
Format: Article
Language:English
Published: BMJ Publishing Group 2019-11-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Bispecific T cell engagers
Tumour-associated macrophages
Oncolytic virus
Tumour microenvironment
Online Access:http://link.springer.com/article/10.1186/s40425-019-0807-6

Internet

http://link.springer.com/article/10.1186/s40425-019-0807-6

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