The Effects of NT-1044, a Novel AMPK Activator, on Endometrial Cancer Cell Proliferation, Apoptosis, Cell Stress and In Vivo Tumor Growth

The Effects of NT-1044, a Novel AMPK Activator, on Endometrial Cancer Cell Proliferation, Apoptosis, Cell Stress and In Vivo Tumor Growth

ObjectivesAnti-diabetic biguanide drugs such as metformin may have anti-tumorigenic effects by behaving as AMPK activators and mTOR inhibitors. Metformin requires organic cation transporters (OCTs) for entry into cells, and NT-1044 is an AMPK activator designed to have greater affinity for two of th...

Full description

Bibliographic Details
Main Authors: Dario R. Roque, Lu Zhang, Weiya Z. Wysham, Jianjun Han, Wenchuan Sun, Yajie Yin, James N. Livingston, Ken W. Batchelor, Chunxiao Zhou, Victoria L. Bae-Jump
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
NT-1044
metformin
endometrial cancer
obesity
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.690435/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.690435/full

Similar Items