Upregulation of NAD(P)H:Quinone Oxidoreductase By Radiation Potentiates the Effect of Bioreductive β-Lapachone on Cancer Cells

Upregulation of NAD(P)H:Quinone Oxidoreductase By Radiation Potentiates the Effect of Bioreductive β-Lapachone on Cancer Cells

We found that (β-Lapachone ((β-Lap), a novel bioreductive drug, caused rapid apoptosis, clonogenic cell death in A549 human lung epithelial cancer cells in vitro in a dose-dependent manner. The clonogenic cell death caused by (β-Lap could be significantly inhibited by dicoumarol, an inhibitor of NA...

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Bibliographic Details
Main Authors: Eun K. Choi, Kaoru Terai, In-Mi Ji, Yeon H. Kook, Kyung H. Park, Eun T. Oh, Robert J. Griffin, Byung U. Lim, Jin-Seok Kim, Doo S. Lee, David A. Boothman, Melissa Loren, Chang W. Song, Heon Joo Park
Format: Article
Language:English
Published: Elsevier 2007-08-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
N001
radiation
p-Lapachone
A549 cells
Bioreductive drug
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800704

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http://www.sciencedirect.com/science/article/pii/S1476558607800704

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