Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo — in search of potential anti-epileptogenic strategies for temporal lobe epilepsy

Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo — in search of potential anti-epileptogenic strategies for temporal lobe epilepsy

Abstract Background Previous studies in various rodent epilepsy models have suggested that mammalian target of rapamycin (mTOR) inhibition with rapamycin has anti-epileptogenic potential. Since treatment with rapamycin produces unwanted side effects, there is growing interest to study alternatives t...

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Bibliographic Details
Main Authors: C. M. Drion, J. van Scheppingen, A. Arena, K. W. Geijtenbeek, L. Kooijman, E. A. van Vliet, E. Aronica, J. A. Gorter
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Neuroinflammation
Subjects:
Rapamycin
Curcumin
Inflammation
Oxidative stress
Temporal lobe epilepsy
mTOR
Online Access:http://link.springer.com/article/10.1186/s12974-018-1247-9

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http://link.springer.com/article/10.1186/s12974-018-1247-9

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