ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity[S]

ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity[S]

ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-poor apolipoprotein A-I (apoA-I) and generates HDL. Here, we demonstrate that ABCA1 also directly mediates the production of apoA-I free microparticles. In baby hamster kidney (BHK) cells and RAW macrophages, ABCA1 expr...

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Bibliographic Details
Main Authors: Shilpi Nandi, Loretta Ma, Maxime Denis, Joel Karwatsky, Zhiqiang Li, Xian-Cheng Jiang, Xiaohui Zha
Format: Article
Language:English
Published: Elsevier 2009-03-01
Series:Journal of Lipid Research
Subjects:
apoA-I
macrophages
wheat germ agglutinin
plasma membrane
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520308890

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520308890

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