iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling

iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling

Abstract Background Epithelial–mesenchymal transition (EMT) and dysregulated microRNAs (miRNAs) have important roles in driving chemoresistance. We previously reported that iASPP is a key EMT inducer and could increase cisplatin resistance in cervical cancer (CC) cells. Herein, we investigate the do...

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Bibliographic Details
Main Authors: Ying Xiong, Fei Sun, Peixin Dong, Hidemichi Watari, Junming Yue, Min-fei Yu, Chun-yan Lan, Yin Wang, Ze-biao Ma
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cervical cancer
iASPP
EMT
Chemoresistance
FBXL5
BTG3
Online Access:http://link.springer.com/article/10.1186/s13046-017-0520-6

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http://link.springer.com/article/10.1186/s13046-017-0520-6

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