Pathway-wide association study implicates multiple sterol transport and metabolism genes in HDL cholesterol regulation

Pathway-wide association study implicates multiple sterol transport and metabolism genes in HDL cholesterol regulation

Pathway-based association methods have been proposed to be an effective approach in identifying disease genes, when single-marker association tests do not have sufficient power. The analysis of quantitative traits may be benefited from these approaches, by sampling from two extreme tails of the dist...

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Bibliographic Details
Main Authors: Kai eWang, Andrew C Edmondson, Mingyao eLi, Fan eGao, Atif N Qasim, Joseph M Devaney, Mary Susan eBurnett, Dawn M Waterworth, Vincent eMooser, Struan F.A. Grant, Stephen E Epstein, Muredach P Reilly, Hakon eHakonarson, Daniel J Rader
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-07-01
Series:Frontiers in Genetics
Subjects:
Cholesterol
GWAS
Genetic association
Lipid
pathway analysis
sterol metabolism
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2011.00041/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2011.00041/full

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