Inflammatory Stress Potentiates Emodin-Induced Liver Injury in Rats

Inflammatory Stress Potentiates Emodin-Induced Liver Injury in Rats

Herbal medicines containing emodin, widely used for the treatment of hepatitis in clinic, have been reported with hepatotoxicity in individuals. A modest inflammatory stress potentiating liver injury has been linked to the idiosyncratic drug-induced liver injury (IDILI). In this study, we investigat...

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Bibliographic Details
Main Authors: Can eTu, Dan eGao, Xiao-fei eLi, Chun-yu eLi, Rui-sheng eLi, Yan-ling eZhao, Na eLi, Ge-liu-chang eJia, Jing-yao ePang, He-rong eCui, Zhi-jie eMa, Xiao-he eXiao, Jia-Bo eWang
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Pharmacology
Subjects:
Emodin
Hepatotoxicity
lipopolysaccharide (LPS)
Proinflammatory mediators
Therapeutic dosages
idiosyncratic drug-induced liver injury (IDILI)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00233/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00233/full

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