The Deubiquitinase USP39 Promotes ESCC Tumorigenesis Through Pre-mRNA Splicing of the mTORC2 Component Rictor

The Deubiquitinase USP39 Promotes ESCC Tumorigenesis Through Pre-mRNA Splicing of the mTORC2 Component Rictor

Spliceosomes are large RNA-protein molecular complexes which mediate splicing of pre-mRNA in eukaryotic cells. Their function is frequently altered in cancer, providing opportunities for novel therapeutic approaches. The ubiquitin specific protease 39 (USP39) is a highly conserved deubiquitylation f...

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Bibliographic Details
Main Authors: Yuan Zhao, Huiwu Geng, Gang Liu, Qiang Ji, Xiaomin Cheng, Xinying Li, Wei Liu, Rick F. Thorne, Renquan Zhang, Xiaoying Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
esophageal squamous cell carcinoma (ESCC)
ubiquitin specific protease 39 (USP39)
mammalian target of rapamycin (mTOR)
RNA splicing
rictor
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.667495/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.667495/full

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