Origin of a folded repeat protein from an intrinsically disordered ancestor

Origin of a folded repeat protein from an intrinsically disordered ancestor

Repetitive proteins are thought to have arisen through the amplification of subdomain-sized peptides. Many of these originated in a non-repetitive context as cofactors of RNA-based replication and catalysis, and required the RNA to assume their active conformation. In search of the origins of one of...

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Bibliographic Details
Main Authors: Hongbo Zhu, Edgardo Sepulveda, Marcus D Hartmann, Manjunatha Kogenaru, Astrid Ursinus, Eva Sulz, Reinhard Albrecht, Murray Coles, Jörg Martin, Andrei N Lupas
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-09-01
Series:eLife
Subjects:
TPR
ancient peptides
ribosomal protein
protein evolution
protein folding
amplification
Online Access:https://elifesciences.org/articles/16761

Internet

https://elifesciences.org/articles/16761

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