Tacrolimus‐induced hypomagnesemia and hypercalciuria requires FKBP12 suggesting a role for calcineurin

Tacrolimus‐induced hypomagnesemia and hypercalciuria requires FKBP12 suggesting a role for calcineurin

Abstract Calcineurin inhibitors (CNIs) are immunosuppressive drugs used to prevent graft rejection after organ transplant. Common side effects include renal magnesium wasting and hypomagnesemia, which may contribute to new‐onset diabetes mellitus, and hypercalciuria, which may contribute to post‐tra...

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Bibliographic Details
Main Authors: Brittany D. K. Gratreak, Elizabeth A. Swanson, Rebecca A. Lazelle, Sabina K. Jelen, Joost Hoenderop, René J. Bindels, Chao‐Ling Yang, David H. Ellison
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Physiological Reports
Subjects:
calcineurin inhibitor
calcium
distal tubule
magnesium
tacrolimus
Online Access:https://doi.org/10.14814/phy2.14316

Internet

https://doi.org/10.14814/phy2.14316

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