A modified vaccinia Ankara virus (MVA) vaccine expressing African horse sickness virus (AHSV) VP2 protects against AHSV challenge in an IFNAR -/- mouse model.

A modified vaccinia Ankara virus (MVA) vaccine expressing African horse sickness virus (AHSV) VP2 protects against AHSV challenge in an IFNAR -/- mouse model.

African horse sickness (AHS) is a lethal viral disease of equids, which is transmitted by Culicoides midges that become infected after biting a viraemic host. The use of live attenuated vaccines has been vital for the control of this disease in endemic regions. However, there are safety concerns ove...

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Bibliographic Details
Main Authors: Javier Castillo-Olivares, Eva Calvo-Pinilla, Isabel Casanova, Katarzyna Bachanek-Bankowska, Rachael Chiam, Sushila Maan, Jose Maria Nieto, Javier Ortego, Peter Paul Clement Mertens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3027694?pdf=render

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http://europepmc.org/articles/PMC3027694?pdf=render

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