MLIF Modulates Microglia Polarization in Ischemic Stroke by Targeting eEF1A1

MLIF Modulates Microglia Polarization in Ischemic Stroke by Targeting eEF1A1

Monocyte locomotion inhibitory factor (MLIF) is a heat-stable pentapeptide from Entamoeba histolytica. Our previous study found that MLIF protects against ischemic stroke in rats and mice and exerts a neuroprotection effect in human neuroblastoma SH-SY5Y cells. Microglia/macrophage polarization has...

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Bibliographic Details
Main Authors: Yulan Liu, Shanshan Deng, Zhibing Song, Qian Zhang, Yuchen Guo, Yongsheng Yu, Yuliang Wang, Tiejun Li, Fayed A. K. Megahed, Tamer A. Addissouky, Junqin Mao, Yuefan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
brain ischemia
microglia polarization
inflammation
monocyte locomotion inhibitory factor (MLIF)
eukaryotic translation elongation factor 1A1 (eEF1A1)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.725268/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.725268/full

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