Single-cell protein-mRNA correlation analysis enabled by multiplexed dual-analyte co-detection

Single-cell protein-mRNA correlation analysis enabled by multiplexed dual-analyte co-detection

Abstract We have investigated the correlation between proteins and mRNAs in single cells employing an integrated workflow for dual-analyte co-detection. This is achieved by combining the oligo extension reaction (OER), which converts protein levels to DNA levels, with reverse transcription for mRNA...

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Bibliographic Details
Main Authors: Haibiao Gong, Xiaohui Wang, Benjamin Liu, Stephane Boutet, Ilona Holcomb, Gajalakshmi Dakshinamoorthy, Aik Ooi, Chad Sanada, Gang Sun, Ramesh Ramakrishnan
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03057-5

Internet

https://doi.org/10.1038/s41598-017-03057-5

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