Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration.

Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration.

The expression of soluble growth and survival promoting factors by neural precursor cells (NPCs) is suggested to be a prominent mechanism underlying the protective and regenerative effects of these cells after transplantation. Nevertheless, how and to what extent specific NPC-expressed factors contr...

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Bibliographic Details
Main Authors: Lalitha Madhavan, Brian F Daley, Beverly L Davidson, Ryan L Boudreau, Jack W Lipton, Allyson Cole-Strauss, Kathy Steece-Collier, Timothy J Collier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4560385?pdf=render

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http://europepmc.org/articles/PMC4560385?pdf=render

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