System vaccinology for the evaluation of influenza vaccine safety by multiplex gene detection of novel biomarkers in a preclinical study and batch release test.

Vaccines are beneficial and universal tools to prevent infectious disease. Thus, safety of vaccines is strictly evaluated in the preclinical phase of trials and every vaccine batch must be tested by the National Control Laboratories according to the guidelines published by each country. Despite many...

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Bibliographic Details
Main Authors: Takuo Mizukami, Haruka Momose, Madoka Kuramitsu, Kazuya Takizawa, Kumiko Araki, Keiko Furuhata, Ken J Ishii, Isao Hamaguchi, Kazunari Yamaguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4092028?pdf=render