In silico Prioritization of Transporter–Drug Relationships From Drug Sensitivity Screens

In silico Prioritization of Transporter–Drug Relationships From Drug Sensitivity Screens

The interplay between drugs and cell metabolism is a key factor in determining both compound potency and toxicity. In particular, how and to what extent transmembrane transporters affect drug uptake and disposition is currently only partially understood. Most transporter proteins belong to two prote...

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Bibliographic Details
Main Authors: Adrián César-Razquin, Enrico Girardi, Mi Yang, Marc Brehme, Julio Saez-Rodriguez, Giulio Superti-Furga
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
solute carriers
ABC transporters
drug sensitivity and resistance
drug transport
regularized linear regression
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01011/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01011/full

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