Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.

Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.

Galectin-9 ameliorates various murine autoimmune disease models by regulating T cells and macrophages, although it is not known what role it may have in B cells. The present experiment shows that galectin-9 ameliorates a variety of clinical symptoms, such as proteinuria, arthritis, and hematocrit in...

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Main Authors: Masahiro Moritoki, Takeshi Kadowaki, Toshiro Niki, Daisuke Nakano, Genichiro Soma, Hirohito Mori, Hideki Kobara, Tsutomu Masaki, Masakazu Kohno, Mitsuomi Hirashima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3621869?pdf=render

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http://europepmc.org/articles/PMC3621869?pdf=render

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