Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

Induction of intestinal drug metabolizing enzymes can complicate the development of new drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in pharmacokinetics, safety and efficacy. The development of a human-relevant model of the adult intestine that accurately p...

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Bibliographic Details
Main Authors: Magdalena Kasendra, Raymond Luc, Jianyi Yin, Dimitris V Manatakis, Gauri Kulkarni, Carolina Lucchesi, Josiah Sliz, Athanasia Apostolou, Laxmi Sunuwar, Jenifer Obrigewitch, Kyung-Jin Jang, Geraldine A Hamilton, Mark Donowitz, Katia Karalis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
Organs-on-Chips
organoids
duodenum
CYP3A4
drug transport
drug metabolism
Online Access:https://elifesciences.org/articles/50135

Internet

https://elifesciences.org/articles/50135

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