Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis

Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis

Abstract Background Regulatory T cells (Tregs) play a role in the suppression of inflammation in autoimmune diseases, and lymphocyte activation gene 3 (LAG3) was reported as a marker of interleukin (IL)-10-producing Tregs. We aimed to clarify the function of human IL-10-producing CD4+CD25−LAG3+ T ce...

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Bibliographic Details
Main Authors: Shinichiro Nakachi, Shuji Sumitomo, Yumi Tsuchida, Haruka Tsuchiya, Masanori Kono, Rika Kato, Keiichi Sakurai, Norio Hanata, Yasuo Nagafuchi, Shoko Tateishi, Hiroko Kanda, Tomohisa Okamura, Kazuhiko Yamamoto, Keishi Fujio
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Arthritis Research & Therapy
Subjects:
LAG3
Regulatory T cell
IL-10
Abatacept
Rheumatoid arthritis
Antibody production
Online Access:http://link.springer.com/article/10.1186/s13075-017-1309-x

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http://link.springer.com/article/10.1186/s13075-017-1309-x

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