Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation

Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation

Rab GTPases are implicated in endosome-to-plasma membrane recycling, but how such membrane traffic regulators control vascular endothelial growth factor receptor 2 (VEGFR2/KDR) dynamics and function are not well understood. Here, we evaluated two different recycling Rab GTPases, Rab4a and Rab11a, in...

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Bibliographic Details
Main Authors: Helen M. Jopling, Adam F. Odell, Caroline Pellet-Many, Antony M. Latham, Paul Frankel, Asipu Sivaprasadarao, John H. Walker, Ian C. Zachary, Sreenivasan Ponnambalam
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Cells
Subjects:
endothelial
VEGF-A
VEGFR2
Rab4a
Rab11a
signalling
angiogenesis
Online Access:http://www.mdpi.com/2073-4409/3/2/363

Internet

http://www.mdpi.com/2073-4409/3/2/363

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